Do you have enough connections defined in the pool?
One of the reasons to get a timeout under load is to have to wait for a connection availability. If the pool is fully utilized, this may happen.
Also the 10MB payload makes me think you need to use a CCDTURL in order to set the max message length on the client channel. 10 MB is more than twice the default of 4 MB.
On top of that make sure the sharing of sockets is minimized. 10 MB takes some time to traverse the socket and you don't want to spend this time waiting...
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